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Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat
Marie Claire Tchamadeu,
Rosange Yefou Tsangue,
Calvin Zangue Bogning,
Christian Takoukam Ténézoguang,
Patience Emambo,
Paul Désiré Djomeni Dzeufiet,
Alain Bertrand Dongmo
Issue:
Volume 8, Issue 1, March 2022
Pages:
1-12
Received:
20 December 2021
Accepted:
17 January 2022
Published:
16 February 2022
Abstract: Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not on type 2 diabetes yet. Objective: To evaluate preventive effects of P. soyauxii Taub aqueous stem bark extract on dexamethasone–induced insulin resistance and oxidative stress in rat. Materials and Methods: Glucose-overloaded normal Wistar rats were administered with P. soyauxii aqueous plant extract at various doses (38–300 mg.kg) in a single administration. Then, dexamethasone (Dex)–induced insulin-resistant rats received sub-chronic daily administration of the plant extract (38–300 mg/kg) for 21 days. Glibenclamide (10 mg/kg) and metformin (200 mg/kg) were respectively used in each test as standard treatments. Fasting blood glucose was followed for over 3 h in acute test. In sub-chronic test, body weight was followed weekly, glycemia before and at the end of treatment, and insulin sensitivity and serum and tissue biochemical parameters evaluated at the end of treatment. Results: Single administration of the plant extract significantly reduced (p<0.05) the serum glucose level increase of glucose-overloaded rats at lower doses, compared to hyperglycemic control. Its prolonged administration with dexamethasone in normal rats prevented insulin-resistance at all doses (p<0.001) similarly to metformin, without decreasing the body weight loss. The extract also prevented significantly (p<0.001) dexamethasone-induced increased serum creatinine, triglyceride, LDL-cholesterol, and transaminases, and decreased total proteins and HDL-cholesterol. Moreover, it improved significantly (p<0.05 – p<0.001) tissues oxidative stress parameters. Conclusion: P. soyauxii Taub aqueous stem bark extract can prevent the onset of type 2 diabetes.
Abstract: Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not on type 2 diabetes yet. Objective: To evaluate preventive effects of P. soyauxii Taub aqueous stem bark extract on dexamethasone–induced insulin resistance and oxidative stress in rat. Materials and Methods: Glucose-overloaded normal W...
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Effect of Neem and Tamarind Leaves as Anthelmintic in Cattle
Atikur Rahaman,
Syed Ali Azmal,
Shiekh M. A. Matin,
Nazmul Haque,
Md. Ruhul Amin,
Md. Ahsanul Kabir
Issue:
Volume 8, Issue 1, March 2022
Pages:
13-15
Received:
23 January 2022
Accepted:
9 February 2022
Published:
16 February 2022
Abstract: Neem (Azadirachta indica) and Tamarind (Tamarindus indica) leaves are used worldwide for their wide range of medicinal properties like antibacterial, antiprotozoal, hepato-protective and other properties. The present study was conducted to observe the effects of Neem (Azadirachta indica) and Tamarind (Tamarindus indica) leaves as anthelmintics in cattle. Animals were selected and grouped into four groups where Group A was considered as control, Group B was treated with grinded Neem leaves, Group C was treated with grinded Tamarind leaves and Group D was treated with both grinded Neem leaves and Tamarind leaves and the efficacy rate was calculated. It was observed that Neem and Tamarind leaves had a significant effect on the number of fecal eggs count. On day 0 average egg counts of A, B, C and D were recorded 7.50±0.45, 7.80±0.50, 7.95±0.38 and 8.00±0.52 respectively. However, on the 15th-day number of eggs was significantly decreased (P≤0.05) in treatment groups. Moreover, considering efficacy it was observed that Neem: Tamarind (1:1) was more efficient (68.15%) than individual Neem (29.93%) and Tamarind (42.67%). Hence, Neem and Tamarind leaves were found effective as anthelmintics in cattle.
Abstract: Neem (Azadirachta indica) and Tamarind (Tamarindus indica) leaves are used worldwide for their wide range of medicinal properties like antibacterial, antiprotozoal, hepato-protective and other properties. The present study was conducted to observe the effects of Neem (Azadirachta indica) and Tamarind (Tamarindus indica) leaves as anthelmintics in c...
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Identification and Documentation of Ethno-veterinary Remedies Used by Afar Pastoralists for the Treatment of Camel Diseases in Ethiopia
Fekadu Gutema Wegi,
Weldegebrial Gebrezgabher Aregawi,
Juhar Tesfaye Bekele,
Abel Sorsa Gelatu
Issue:
Volume 8, Issue 1, March 2022
Pages:
16-23
Received:
17 February 2022
Accepted:
7 March 2022
Published:
15 March 2022
Abstract: Background: Ethnoveterinary medicine is a scientific term for traditional animal health care that encompasses knowledge, belief, practice and skill of the community used for curing diseases and maintaining health of animals. A cross-sectional study was conducted using semi-structured questionnaires from September 2016 to August 2017 to gather information on the knowledge, practice and skill of the pastoralists and traditional healers about the importance and application of Ethno-veterinary medicine. Moreover, this study was conducted with the objectives of identification and documentation of major ethno-veterinary medicinal plants commonly used to treat camel aliments in Afar region. Result: A total of 146 traditional healers and pastoralists were interviewed for baseline and reliable information about Ethno-veterinary medicinal practice in Afar region. Accordingly, 99.3% of the respondents were men in which 66.44% of them were in the age range of 45-60. Majorities (76.02%) of the information’s concerning EVM were obtained from the elders among which 84.93% responded that the overall EVM practice and status in pastoral society of Afar is decreasing. A total of 710 plant species supposed to have medicinal property were recommended by pastoralists to be used for the treatment of 49 different animal diseases. Among 64 plants specimen collected, Balanites aegyptia, Cissus rotundifolia (Forssk.) Vahl, Cadaba rotundifolia Forssk, Solanum sp, Acalypha indica L and Tamarix aphylla (L.) Karsts were the commonly used plant species with high fidelity value. Concerned with plant parts used, leaf (20.5%) was the most frequently used plant parts followed by root (19.4%), fruit (14.4%), seed (10.8%) and entire plant (8.8%). These herbal remedies were administered orally, nasally, ocular and topically. Conclusion: pastoralists and traditional healers in Afar region have immense indigenous knowledge and practices of treating sick animals which should be supported by scientific techniques for analyzing the active ingredients contained in each plant species and for evaluating the safety, efficacy and dosage of the commonly used medicinal plants. In addition, on station establishment of commonly used medicinal plant nursery for conservation purpose and to conduct in-depth phytochemical analysis is paramount important.
Abstract: Background: Ethnoveterinary medicine is a scientific term for traditional animal health care that encompasses knowledge, belief, practice and skill of the community used for curing diseases and maintaining health of animals. A cross-sectional study was conducted using semi-structured questionnaires from September 2016 to August 2017 to gather infor...
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