Hepatoprotective and Antioxidant Role of Ziziphus jujuba Leaves on Paracetamol Induced Hepatic Damage in Rats
J. Preethi,
K. Vennila,
S. Penislusshiyan,
S. Velvizhi
Issue:
Volume 2, Issue 1-1, February 2016
Pages:
1-10
Received:
5 January 2016
Accepted:
20 January 2016
Published:
23 February 2016
Abstract: To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of aqueous leaf extract of Ziziphus jujuba leaves. Animals were pre-treated with the aqueous leaf extract for 7 days and then toxicity was induced with a single paracetamol oral injection. Pre-treatment with 150mg/kg of aqueous leaf extract of Ziziphus jujuba improved the reduced glutathione (oxidized), SOD, catalase, and peroxidase levels significantly as compared to control group. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. The biochemical observation was reported for rat liver sections. The results of this study strongly indicate that Ziziphus jujuba leaves have potent hepatoprotective action against paracetamol induced hepatic damage in rats. Aqueous extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for aqueous extracts. On the basis of this study, we conclude that aqueous extract of Ziziphus jujuba possesses in vivo antioxidant activity and can be employed in protecting tissues from oxidative damage and stress.
Abstract: To evaluate the hepatoprotective activity of aqueous extract of Ziziphus jujuba leaves against paracetamol-induced liver injury in experimental rats. Ziziphus jujuba has been traditionally used in the Ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective a...
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Anti-diabetic Effect of Myrtenal on Plasma and Tissue Glycoproteins Components in STZ Induced Experimental Diabetic Rats
Leelavinothan Pari,
Ayyasamy Rathinam
Issue:
Volume 2, Issue 1-1, February 2016
Pages:
11-16
Received:
14 August 2015
Accepted:
1 September 2015
Published:
23 February 2016
Abstract: The aim of present study was to evaluate the effect of myrtenal, a monoterpene on plasma and tissues glycoprotein components in streptozotocin-induced diabetic rats. Diabetes was induced in overnight fasted experimental rats by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight) dissolved in 0.1 M citrate buffer at pH 4.5. STZ-injected animals were given 20 % glucose solution for 24 h to prevent initial drug-induced hypoglycemia mortality. The levels of plasma glucose, plasma and tissues glycoproteins such as hexose, hexosamine, fucose and sialic acid were significantly increased whereas plasma insulin levels were significantly decreased in diabetic rats. On oral administration myrtenal (80 mg/kg b.w.) once daily to diabetic rats for the period of 28 days brought back the levels of plasma and tissues glycoprotein components. Based on the present study, we propose that myrtenal possesses significant protective effect on glycoprotein metabolism.
Abstract: The aim of present study was to evaluate the effect of myrtenal, a monoterpene on plasma and tissues glycoprotein components in streptozotocin-induced diabetic rats. Diabetes was induced in overnight fasted experimental rats by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight) dissolved in 0.1 M citrate buffer at pH 4...
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