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In Vitro Therapeutic Potential of Leaf Extract of Eugenia uniflora linn on Acute – inflammation Rat Model
Elizabeth Finbarrs Bello,
Abireh Ifeanacho Ezeteonu,
Ude Vincent
Issue:
Volume 6, Issue 2, June 2020
Pages:
31-38
Received:
27 February 2020
Accepted:
18 March 2020
Published:
12 May 2020
Abstract: The leaves of Eugenia uniflora are used as anti-inflammatory and analgesic in the treatment of tissue injury in traditional medicine. The study evaluates the anti-inflammatory, analgesic, hematological and histological effects of ethanol extract of E. uniflora. The anti-inflammatory effect was accessed in test groups given different doses (50, 100 and 200 mg/kg, p. o) of the extract, a control group (0.1 mL/kg, normal saline) and standard drug group (Ibuprofen 100mg/kg, p. o) on formalin- induced paw edema. Body weight, paw weight, thickness and volume were evaluated. Analgesic property was accessed on separate group of animals by acetic acid-induced writhing and formalin-induced paw licking tests. Thereafter, hematological parameters were estimated and sections of the edematous skin were processed and stained with H and E. The Eugenia uniflora decreased paw volume and thickness after 3hr. There was dose dependent significant (P<0.05) decrease in the number of abdominal writhing and insignificant reduction in the second or late phases of formalin-induced paw licking test group. Reduction in RBC, HB, PCV and increase in platelet, ESR, WBC were observed in the formalin-induced paw edema group. Histopathological assessment revealed aggregation of inflammatory cells in skin sections of the untreated group of the formalin-induced paw edema but a noticeable reversal in the extract and Ibuprofen treatment groups. These profiles indicate E. uniflora has potent anti-inflammatory and analgesic effects comparable to Ibuprofen a non steroidal anti-inflammatory drug (NSAIDs) and justifies it use in the treatment of inflammation and local tissue injury.
Abstract: The leaves of Eugenia uniflora are used as anti-inflammatory and analgesic in the treatment of tissue injury in traditional medicine. The study evaluates the anti-inflammatory, analgesic, hematological and histological effects of ethanol extract of E. uniflora. The anti-inflammatory effect was accessed in test groups given different doses (50, 100 ...
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The Effects of Sida corymbosa Leaf Extract Against Abnormal Bilirubin and Total Protein in Albino Rats by Carbon Tetrachloride (CCl4)
Dike Charles Chijioke,
Ezeonu Francis Chukwuemeka,
Maduka Hugh Clifford Chima,
Ezeokafor Emmanuel Nonso,
Okpogba Aloysius Ngozika,
Oguazu Chinenye Enoch,
Eyeghre Onoriode Akpoghene,
Asebioyo Sunday Jacob
Issue:
Volume 6, Issue 2, June 2020
Pages:
39-44
Received:
30 January 2020
Accepted:
13 February 2020
Published:
15 June 2020
Abstract: The Sida corymbosa plant has been used for centuries in traditional medicine in different countries for prevention and treatment of different diseases such as liver and cardiac diseases. This work aimed at investigating if Sida corymbosa ethanolic leaf extract has preventive and therapeutic effects against abnormal serum bilirubin and total protein in Albino rats by carbon tetrachloride (CCl4). This study took place at Nnamdi Azikiwe University, Nnewi Campus, Anambra State. The rats were grouped into those given 5000, 3000 and 1000 mg/kgbw of the extract before and after CCl4 administration from 7 d to 28 d, those injected CCl4 only which stayed from 7 d to 28 d and those without CCl4 and extract. Male Albino rats weighing 170-190 g were used. Injection of CCl4 (0.4 ml/kgbw i.p) was done using olive as vector before and after oral administration of the Sida corymbosa extract. Serum bilirubin was estimated using Powel’s method while serum total protein was estimated using the Biuret method. Results were analyzed statistically using SPSS statistical software version 21. Analysis done so far revealed that serum bilirubin of rats injected CCl4 without extract administration (negative control) was significantly higher (P<0.05) than other groups, those administered 5000, 3000 and 1000 mg/kgbw of extract before and after CCl4 injection and those without CCl4 nor extract (positive control). The reverse was the case for serum total protein, suggesting protective and therapeutic potentials of the extract. Sida corymbosa ethanolic leaf extract may, therefore, has some protective and therapeutic effects against abnormal serum bilirubin and total protein synthesis in Albino rats by CCl4 thereby improving the liver function.
Abstract: The Sida corymbosa plant has been used for centuries in traditional medicine in different countries for prevention and treatment of different diseases such as liver and cardiac diseases. This work aimed at investigating if Sida corymbosa ethanolic leaf extract has preventive and therapeutic effects against abnormal serum bilirubin and total protein...
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Phytochemical Analysis of Daucus Carota and Zingiber officinale Samples Collected from Gwarimpa Abuja Nigeria
Abdulrasheed Hadiza Haruna,
Akilu Mariya,
Mohammed Mairo
Issue:
Volume 6, Issue 2, June 2020
Pages:
45-49
Received:
24 June 2020
Accepted:
20 July 2020
Published:
28 July 2020
Abstract: This study aims at determining the phytochemical potentials of Daucus carota and Zingiber officinale collected from a location in Abuja, FCT. Standard laboratory procedures were employed to achieve the objectives. To ascertain the presence of phytochemical components which may be responsible for the healing and ethno-medicinal properties, a qualitative and quantitative screening of the extracts of the sampled plants was conducted. Daucus carota and Zingiber officinale were collected from Kado Bimko market, Gwarinpa, Abuja in October, 2016. Vegetable samples were washed, chopped into uniform sizes and dehydrated into powder form in preparation for further analysis. The phytochemical screening of chemical constituents of the vegetable extracts were carried out to confirm if they contain some notable phytochemicals in them, the result obtained showed some differences in the two samples tested, tannins, alkaloids, flavonoids, Terpenes, steroids, Anthraquinones, and resins were present in zingiber officianale sample while daucus carota showed presence of tannins, saponins, flavonoids, glycosides, terpenes, steroids, phenols, and resins. The presence of these important plant constituents suggests that these vegetables could be potential sources of phytochemicals, which are responsible for their curative and healing properties. This however confirms that they can be used in drug development and treatment and management of various diseases in Nigeria.
Abstract: This study aims at determining the phytochemical potentials of Daucus carota and Zingiber officinale collected from a location in Abuja, FCT. Standard laboratory procedures were employed to achieve the objectives. To ascertain the presence of phytochemical components which may be responsible for the healing and ethno-medicinal properties, a qualita...
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Phytochemical Analysis of Some Selected Indigenous Fruits Collected from Lokogoma-Abuja, Nigeria
Akilu Mariya,
Abdulrasheed Hadiza Haruna,
Akilu Zakari Babangida
Issue:
Volume 6, Issue 2, June 2020
Pages:
50-55
Received:
1 July 2020
Accepted:
14 July 2020
Published:
28 July 2020
Abstract: Fruits, vegetables, and other plant-based foods are rich in bioactive phytochemicals that may provide desirable health benefits beyond basic nutrition to reduce the risk of the development of chronic diseases (Liu, 2004). This study focuses on determining the presence of phytochemical components in Citrillus lanatus (Watermelon), Musa acuminate (Banana), Psidium guajava (Guava) and Solanum lycopersicum (Tomato) samples collected from a location in Abuja, FCT. The set objectives were achieved using the standard laboratory procedures as sourced from literature. To determine the presence of phytochemical components responsible for the medicinal properties, a qualitative screening checking for ten (10) known phytochemicals was conducted for each fruit extract. The Phytochemicals screened for were Tannins, Saponins, Alkaloids, Flavonoids, Glycosides, Terpenes, Steroids, Phenols, Resins and Anthraquinones. All sampled fruit revealed the presence of a number of the phytochemicals checked, but no fruit sample tested positive for all phytochemicals tested. The Citrillus lanatus was the only sample to test positive for Flavonoids and negative for Anthraquinones. The phytochemicals found in these fruits have a wide range of therapeutic indications with a great variety of biological properties such as antioxidant, provitamin, antibacterial, antiviral, anticancer and anti-inflammatory activities. The present data suggests that the crude ethanolic extracts of the sample fruits are potential sources of phytochemicals that could be of great importance to the health and nutrition of humans and in the treatment of various diseases.
Abstract: Fruits, vegetables, and other plant-based foods are rich in bioactive phytochemicals that may provide desirable health benefits beyond basic nutrition to reduce the risk of the development of chronic diseases (Liu, 2004). This study focuses on determining the presence of phytochemical components in Citrillus lanatus (Watermelon), Musa acuminate (Ba...
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