Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark Prevents Hypertension, Oxidative Stress and Dyslipidemia in L-NAME Induced Hypertension in Wistar Rats
Tsague Marthe Valentine,
Fokunang N. Charles,
Tembe Achick Estella,
Mvondo Anne Mauricette,
Afane Ela Anatole,
Oben E. Julius,
Ngadjui Tchaleu Bonaventure,
Ntchapda Fidèle,
Sokeng Dongmo Sélestin,
Nyangono Biyegue Christine Fernande,
Dimo Théophile,
Ze Minkande Jacqueline
Issue:
Volume 2, Issue 4, August 2016
Pages:
43-50
Received:
22 April 2016
Accepted:
17 May 2016
Published:
16 June 2016
Abstract: Introduction: Eribroma oblongum (Malvaceae) stem bark is used in Cameroonian ethnomedicine to treat various metabolic illnesses including cardiovascular diseases. The present study was designed to investigate the mechanisms of hypotensive effects of hydroethanolic extract of Eribroma oblongum and its cardioprotective effects after a subchronic treatment. Study Design: This was a prospective cross-sectional analytical study Methodology: Preventive effects were studied after oral administration of hydroethanolic extract of Eribroma oblongum (HEEO) (100 mg/kg body weight/day) or captopril (25 mg/kg body weight/day) simultaneously with L-NAME (40 mg/kg body weight/ day) in rats for 28 days. Body weight and food intake were measured after 5 days. At the end of treatment, blood pressure and heart rate were recorded. Aorta, heart, liver and kidneys were weighted. Reduced nitrite, superoxide dismutase, catalase, gluthatione, Malondialdehyde and lipid profile were measured. Results: The extract prevented L-NAME hypertension and improved food intake and body weight of rats. HEEO improved lipid profile and antioxidant status. L-NAME caused a significant (P<0.001) increase in the levels of serum transaminase relative to the normal. L-NAME treated rats had markedly decreased catalase (CAT), superoxide dismutase (SOD), nitrite (NO2-) and reduced glutathione (GSH) levels in the tissue. Also, L-NAME caused a significant (P<0.001) induction of lipid peroxidation (MDA) in the animals tissue relative to the normal range. Administration of HEEO with L- NAME caused significant (P<0.001) inhibition of MDA relative to LNHR and augmented tissue antioxidant indices. Conclusion: The hydroethanolic stem bark extract of Eribroma oblongum showed a promising potential cardioprotective effect in L-NAME induced hypertension. This effect could be due at least in part by improving endothelial function, lipid profile and oxidative status. These findings justify the traditional use of HEEO as treatment in cardiovascular disorders and serve as a promising traditional pharmacopoeia for the development of new chemical entity in the phytomedicine development platform.
Abstract: Introduction: Eribroma oblongum (Malvaceae) stem bark is used in Cameroonian ethnomedicine to treat various metabolic illnesses including cardiovascular diseases. The present study was designed to investigate the mechanisms of hypotensive effects of hydroethanolic extract of Eribroma oblongum and its cardioprotective effects after a subchronic trea...
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Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit
Mohammad Kanedi,
Sutyarso,
Siti Nurjanah,
Lilik Koernia Wahidah
Issue:
Volume 2, Issue 4, August 2016
Pages:
51-55
Received:
15 July 2016
Accepted:
18 July 2016
Published:
26 August 2016
Abstract: Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.
Abstract: Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically test...
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