Ethnobotanical Survey and Biological Activities of Two Lactogenic Plants in the Cascades Region of Burkina Faso
Doukouré Maya,
Bayala Balé,
Tindano Basile,
Belemtougri G. Raymond,
Tamboura H. Hamidou,
Armel Herve Nwabo Kamdje,
Sawadogo Laya
Issue:
Volume 4, Issue 1, February 2018
Pages:
1-8
Received:
18 November 2017
Accepted:
18 December 2017
Published:
28 February 2018
Abstract: An ethnobotanical survey for a better knowledge of lactogenic plants has been conducted in Cascades region of Burkina Faso. Biological activities of the two most used plants were evaluated. The survey concerned 25 species classified into 22 genera and 19 families. The most represented families were Moraceae, Apocynaceae, Fabaceae-Caesalpinioideae and Malvaceae. The most used species were Euphorbia hirta, Calotropis procera and Ficus sycomorus with respectively 16.98%, 13.21% and 13.21% followed by Ficus platyphylla (9.43%) and Carica papaya, Holarrhena floribunda, Scoparia dulcis, Sorghum bicolor, each with 3.77% of frequency use. Plants organs mostly used for medicinal preparation were leaves, whole plant for herbaceous species, fruits and seeds. The main mode of medicinal preparation was decoction with 60.42% of frequency use. The most route of administration was oral (68.75%). Biological activities evaluation concerned Euphorbia hirta and Calotropis procera which were the most used plants. The acute toxicity of aqueous extracts of Calotropis procera (AECP) and Euphorbia hirta (AEEH) showed a LD50 of 2063 and 603 mg/kg body weight (b.w), respectively. These LD50 values permitted to classify these plants as slightly toxic herbal drugs. The uterotrophic test showed that the AECP and AEEH exhibited estrogenic activity. In conclusion, important medicinal plants in the Cascades region of Burkina Faso were used to stimulate or ameliorate lactation. However further studies must be conducted to confirm the traditional use of these plants.
Abstract: An ethnobotanical survey for a better knowledge of lactogenic plants has been conducted in Cascades region of Burkina Faso. Biological activities of the two most used plants were evaluated. The survey concerned 25 species classified into 22 genera and 19 families. The most represented families were Moraceae, Apocynaceae, Fabaceae-Caesalpinioideae a...
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Biofield Energy Based Vitamin D3 Stimulates In vitro Osteoblasts Differentiation in MG-63 Cell line
Patricia Margaret Rowe,
Mahendra Kumar Trivedi,
Alice Branton,
Dahryn Trivedi,
Gopal Nayak,
Mayank Gangwar,
Snehasis Jana
Issue:
Volume 4, Issue 1, February 2018
Pages:
9-17
Received:
15 January 2018
Accepted:
1 February 2018
Published:
8 March 2018
Abstract: In most of the people, bone loss and deterioration of bone structure results in bone disorders such as osteoporosis, arthritis, decreased bone mass, rickets, and deformed bones. Insufficient level of vitamin D3 and calcium in the body are the major causes of bone disorders. The present study aimed to explore the potential of Consciousness Energy Healing based vitamin D3 and DMEM medium on various bone health parameters such as alkaline phosphatase enzyme (ALP) activity, collagen levels and bone mineralization. Both the test items (TI) i.e. vitamin D3 and DMEM medium were divided into two parts. The test items received the Consciousness Energy Healing Treatment by Patricia Margaret Rowe and those samples were labeled as the Biofield Energy Treated (BT) samples, while the other parts of both the sample were denoted as the untreated test items (UT). Cell viability using MTT assay showed that cell viability in tested samples was more than 70% with safe and nontoxic profile on MG-63 cell line. The level of ALP was significantly increased by 230.8% (at 50 µg/mL), 231.3% (at 50 µg/mL), and 253% (at 100 µg/mL) in UT-DMEM+BT-TI, BT-DMEM+UT-TI, and BT-DMEM+BT-TI groups, respectively as compared with the untreated test item and DMEM group. Collagen level was significantly increased by 497.7%, 346.2%, 323%, and 331.4% at 0.1, 1, 10, and 50 µg/mL, respectively in the UT-DMEM+BT-TI group, while 116.3% and 112.8% at 0.1 and 50 µg/mL, respectively in the BT-DMEM+UT-TI group. In addition, 70.5% and 143.6% increased collagen was reported at 10 and 50 µg/mL, respectively in BT-DMEM+BT-TI group as compared with the untreated group. Bone mineralization percentage was significantly increased by 241.3% at 1 µg/mL in UT-DMEM+BT-TI group, while 187.9% and 113.7% at 0.1 and 1 µg/mL, respectively in BT-DMEM+UT-TI group as compared with the untreated group. In addition, BT-DMEM+BT-TI group showed a significant increased bone mineralization by 129.8% at 1 µg/mL as compared with the untreated group. Overall, the experimental data suggested that the Biofield Energy Treated vitamin D3 and DMEM would play an important role in the promotion and maintenance of strong and healthy bones, which improve quality of life. Biofield Energy Treatment might also regulates the osteoblast function, improves bone mineralization, and calcium absorption in wide range of bone disorders along with wide range of adverse health conditions, comprising cancer and certain autoimmune diseases.
Abstract: In most of the people, bone loss and deterioration of bone structure results in bone disorders such as osteoporosis, arthritis, decreased bone mass, rickets, and deformed bones. Insufficient level of vitamin D3 and calcium in the body are the major causes of bone disorders. The present study aimed to explore the potential of Consciousness Energy He...
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Transdermal Drug Delivery of Asiatic Acid Influences Renal Function and Electrolyte Handling in Plasmodium berghei - Infected Sprague-Dawley Male Rats
Mavondo Greanious Alfred,
Musabayane Cephas Tagumirwa
Issue:
Volume 4, Issue 1, February 2018
Pages:
18-29
Received:
24 October 2017
Accepted:
20 November 2017
Published:
3 April 2018
Abstract: Background: Malaria is one of the most important infectious inflammatory diseases worldwide which affects vital organs including gastrointestinal and kidneys. Higher prevalence of malaria related renal failure, current malaria drugs nephrotoxicity and drug resistance to malaria calls for continued research in anti-parasitic as well as anti-disease inflammatory pharmaceuticals. Asiatic acid, a plant phytochemical extract, has antioxidant, pro-oxidant and diuretic properties. Here we report influence of Asiatic acid-pectin hydrogel matrix patch application in P. berghei-infected Sprague Dawley rats on renal function and electrolyte handling. Materials and Methods: Asiatic acid (5mg/kg)-pectin patch was applied on the dorsal neck region of the rat on day 7 post infection and monitored for parasitaemia, and physicochemical changes. Urine and blood were collected for measuring various biochemical parameters to estimate renal function and electrolyte handling. Results: Asiatic acid-pectin patch application had significant influence on food and water intake as well as weight changes, urine electrolytes, glomerular filtration rate, and antioxidant markers together with hormonal changes of aldosterone and vasopressin. Conclusion: Application of the once-off Asiatic acid (5mg/kg)-pectin patch influence renal function and renal electrolyte handling while ameliorating, biochemical and hormonal derangements induced by malaria. Novelty of the Work Here we show for the first time a) the efficacy of Asiatic acid (AA) in suppressing murine malaria by way of administering the phytochemical using the amidated pectin hydrogel matrix patch transdermal drug delivery system, b) diminution of asiatic acid dose applied from 10mg/kg oral to 5mg/kg by transdermal, c) reduction of time once-off patch application from five days to three days, d) attenuation of oxidative and hormonal derangements in malaria and e) the amelioration of renal function together with improvement in renal electrolyte handling. The results may be of benefit in patient care replacing the multiple dosing approaches used in malaria management.
Abstract: Background: Malaria is one of the most important infectious inflammatory diseases worldwide which affects vital organs including gastrointestinal and kidneys. Higher prevalence of malaria related renal failure, current malaria drugs nephrotoxicity and drug resistance to malaria calls for continued research in anti-parasitic as well as anti-disease ...
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Caustic Burns in Adults: Epidemiological, Clinical, Endoscopic and Evolutionary Aspects at Sourô Sanou University Hospital Center in Bobo-Dioulasso
Koura Mâli,
Barro Sié Drissa,
Ouattara Zanga Damien,
Zougmore Honoré,
Napon/Zongo Passolguewindé Delphine,
Zouré Nogogna,
Kamboulé Bébar Euloges,
Sawadogo Appolinaire
Issue:
Volume 4, Issue 1, February 2018
Pages:
30-34
Received:
28 February 2018
Accepted:
19 March 2018
Published:
10 April 2018
Abstract: The ingestion of a caustic product is a frequent and sometimes serious accident which can, in the acute phase, bring into play the vital and functional prognosis. The authors report the results of their experiments on 18 cases of caustic ingestion. This was a retrospective descriptive study conducted from February 2012 to January 2016 in the Hepatogastroenterology department of Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso. All patients over the age of 15 admitted for ingestion of caustics and having undergone upper gastrointestinal endoscopy were included. During the 48-months study period, 18 cases of caustic ingestion were recorded, of which 8 men were a sex ratio of 0.8. The average age was 31.25 ± 13.26 years. Ingestion of caustic was voluntary in 8 out of 10 cases. Ingested product was acidic in 66.67% of cases. The clinical picture was defined by hematemesis (50%) and oral lesions (38.89%). Endoscopic lesions were dominated by stage IIb (50%) of ZARGAR. The evolution was marked by a lethality of 11.11%. Caustic burns of the digestive tract are infrequent but serious in our context. Endoscopy plays a very important role in the diagnosis, but their management remains difficult.
Abstract: The ingestion of a caustic product is a frequent and sometimes serious accident which can, in the acute phase, bring into play the vital and functional prognosis. The authors report the results of their experiments on 18 cases of caustic ingestion. This was a retrospective descriptive study conducted from February 2012 to January 2016 in the Hepato...
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