Oxidative Stress Attenuation in Hiv/Aids Patients on Antiretroviral Drugs by Calyx Juice of Hibiscus sabdariffa Linn (Malvaceae)
Franklin Nyenty Tabe,
Nicolas Njintang Yanou,
Armel Herve Nwabo Kamdje,
Aurélie –Solange Agume Ntso
Issue:
Volume 1, Issue 1, April 2015
Pages:
1-7
Received:
19 April 2015
Accepted:
24 April 2015
Published:
30 April 2015
DOI:
10.11648/j.jdmp.20150101.11
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Abstract: The present study was aimed at evaluating the in vivo antioxidant potential of Hibiscus sabdariffa Linnaeus calyx juice (foléré) in HIV/AIDS patients on antiretroviral therapy. In the study, 5g of dried calyces were decocted with 250 mL of fresh tap water at 95°C for 15 minutes. The experimental design was a case-control randomized blinded trial in which, 58 patients on antiretroviral drugs were divided into 2 groups age-and-sex-matched. The experimental group was served a glass of 250 mL calyx juice per day alongside their antiretroviral treatment while the control group was exclusively on antiretroviral drugs with no available placebo. The trial was run for three (3) months after which blood samples were analyzed for the biochemical aspartate aminotransferase (ASAT) and alanine aminotransferase ALAT) and the hematological CD4, white blood cells (WBCs), red blood cells (RBCs), and hemoglobin (HGB)] parameters. The results show an increase in RBCs and WBCs in the experimental group which on the other hand experienced a decrease in CD4 and HGB. The control group experienced a decrease in RBCs, less decrease in HGB, and a higher decrease in CD4, but with increased WBCs. There was a parallel increase in ALAT and ASAT in both groups, more elevated in the control group.
Abstract: The present study was aimed at evaluating the in vivo antioxidant potential of Hibiscus sabdariffa Linnaeus calyx juice (foléré) in HIV/AIDS patients on antiretroviral therapy. In the study, 5g of dried calyces were decocted with 250 mL of fresh tap water at 95°C for 15 minutes. The experimental design was a case-control randomized blinded trial in...
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Bioactivity and Therapeutic Potential of Plant Extracts in Cancer and Infectious Diseases
Simeon Pierre Chegaing Fodouop,
Richard Tagne Simo,
Jeremie Mbo Amvene,
Emmanuel Talla,
Paul Faustin Seke Etet,
Paul Takam,
Armel Herve Nwabo Kamdje,
Jean-Marc Muller
Issue:
Volume 1, Issue 1, April 2015
Pages:
8-18
Received:
20 April 2015
Accepted:
24 April 2015
Published:
30 April 2015
DOI:
10.11648/j.jdmp.20150101.12
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Abstract: Medicinal plants have been used particularly in resource poor communities of the African continent as an alternative for the treatment of infectious diseases. Traditional medicine plays a critical role in treatment of chronic debilitating and life threatening conditions and infectious diseases. Cancer is one such condition whose therapeutic intervention is commonly through inexpensive traditional herbal remedies. Increasingly industrialised societies are developing drugs and chemotherapeutics from these traditional herbal plants. Plant biogeography determines the abundance and availability of medicinal plants which in turn determine their use by africango communities. Recent findings of bioactivity and therapeutic potential of plant extracts in cancer and infectious diseases are herein summarized and discussed.
Abstract: Medicinal plants have been used particularly in resource poor communities of the African continent as an alternative for the treatment of infectious diseases. Traditional medicine plays a critical role in treatment of chronic debilitating and life threatening conditions and infectious diseases. Cancer is one such condition whose therapeutic interve...
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Medicinal Plants in Breast Cancer Therapy
Tagne Simo Richard,
Armel Herve Nwabo Kamdje,
Farah Mukhtar
Issue:
Volume 1, Issue 1, April 2015
Pages:
19-23
Received:
20 April 2015
Accepted:
24 April 2015
Published:
30 April 2015
DOI:
10.11648/j.jdmp.20150101.13
Downloads:
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Abstract: Various active compounds (or their semi-synthetic derivatives) derived from medicinal plants have been assessed for their efficacy and tolerability in the treatment of breast cancer. Some of these plant species, including Taxus baccata (paclitaxel, docetaxel), Podophyllum peltatum (etoposide), Camptotheca acuminata (camptothecin) and Vinca rosea (vinblastine, vinorelbine) have well recognized antitumour activity in breast cancer, and have been evaluated in clinical trials. For example, results from recent Phase II/III trials have established docetaxel as the most active single agent in the treatment (first or second-line) of advanced metastatic breast cancer. The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Oxidative stress is closely related to various diseases, including cancer. The human body is exposed to free radicals, which cause oxidative stress. Oxidative stress may lead to gene mutations leading to carcinogenesis. Antioxidants are protector of the body, preventing oxidative stress, by stabilizing free radicals. Plants are good and cheap sources for the prevention and treatment of oxidative stress and cancer. Major drawbacks to Antioxidant from plants -based therapy and use in breast cancer are herein briefly discussed.
Abstract: Various active compounds (or their semi-synthetic derivatives) derived from medicinal plants have been assessed for their efficacy and tolerability in the treatment of breast cancer. Some of these plant species, including Taxus baccata (paclitaxel, docetaxel), Podophyllum peltatum (etoposide), Camptotheca acuminata (camptothecin) and Vinca rosea (v...
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