Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities
Nganso Ditchou Yves Oscar,
Tatsimo Ndendoung Simplice Joel,
Amang A. Ngoung Gabrielle Ange,
Soh Desire,
Simo Nemg Fredy Brice,
Nyasse Barthelemy
Issue:
Volume 4, Issue 5, October 2018
Pages:
120-127
Received:
11 October 2018
Accepted:
29 October 2018
Published:
21 November 2018
Abstract: The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.
Abstract: The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many resear...
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Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities
Nganso Ditchou Yves Oscar,
Soh Desire,
Ndogo Eteme Olivier,
Mala Opono M. T. G.,
Nyasse Barthelemy
Issue:
Volume 4, Issue 5, October 2018
Pages:
128-132
Received:
6 October 2018
Accepted:
5 November 2018
Published:
3 December 2018
Abstract: Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.
Abstract: Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4...
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