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The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats
Babaev Khanaga Fizuli,
Shukurova Parvana Agababa,
Ibragimov Anar Shamistan,
Abbasov Ragif Yusub,
Ibragimova Jale Muchtar,
Alieva Ravana Iqbal,
Gasimova Gulnara Zair
Issue:
Volume 8, Issue 2, June 2022
Pages:
24-27
Received:
20 February 2022
Accepted:
15 March 2022
Published:
14 April 2022
Abstract: Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.
Abstract: Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level ...
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Estimation of Soil Constituents Affecting Growth of Medicinal Weed Ipomoea cairica (L.) Sweet
Neha Rauniyar,
Deepa Srivastava
Issue:
Volume 8, Issue 2, June 2022
Pages:
28-33
Received:
18 March 2022
Accepted:
2 April 2022
Published:
26 April 2022
Abstract: The adaptive nature of medicinal plants to their environment is often seen due to their general occurrence. If we consider some wildflower species, they are exceptionally site-specific along with their nature of growth in different soil types and concentrations, so the patchiness of these medicinal plants is often reported in the arable fields. In general occurrence and pattern of space of a medicinal plant is the result of various abiotic factors of the environment among which are soil pH, Bulk density, infiltration rate, and most importantly the nutrient content such as calcium, phosphorous, magnesium, aluminum, iron, etc. which determines the soil type and the rate of growth of vegetation in it. The soil type is important as it determines the water holding capacity of soil which helps the plants to withstand harsh environmental conditions. Thus, the nature of soil affects the growth of medicinal plants in a complex way, while considering it into an account. Thus, it is necessary to identify and quantify the nature of soil required for the growth of medicinal plants luxuriantly, this would in the future help to the cultivation of medicinal plants on a large scale particularly the medicinal plants which has not gained much importance in the past are part of ignorance for human but are very important such as Ipomoea cairica. The current research paper transacts with the purpose of determining how different soil types could affect the nature and growth of medicinal plants i.e., Ipomoea cairica, which is being undomesticated in nature. The research work consists of testing different types of minerals present in both the soil types as well as the pH, Bulk density, Infiltration rate, etc as the determining factor for the growth of a wild Medicinal plant.
Abstract: The adaptive nature of medicinal plants to their environment is often seen due to their general occurrence. If we consider some wildflower species, they are exceptionally site-specific along with their nature of growth in different soil types and concentrations, so the patchiness of these medicinal plants is often reported in the arable fields. In ...
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Molecular Docking Studies of Phytochemicals Against RNA-dependent RNA Polymerase of Mucormycosis
Vikas Jha,
Bhakti Madaye,
Esha Gupta,
Shreya Thube,
Sankalp Kasbe,
Darpan Kaur Matharoo,
Piya Shah,
Mafiz Shaikh,
Arpita Marick
Issue:
Volume 8, Issue 2, June 2022
Pages:
34-40
Received:
24 March 2022
Accepted:
20 April 2022
Published:
29 April 2022
Abstract: Background: Mucormycosis, also referred to as black fungus, is a fatal Angio invasive fungal infection caused by a colony of molds known as mucoromycetes. Rhizopus oryzae is a major fungus that is responsible for almost 70% of the total mucormycosis cases. RNA-dependent RNA polymerase (RdRp), is a crucial enzyme in the RNA polymerization mechanism in various species, including R. oryzae. In the past, inhibiting this enzyme has been found to be a viable technique for eradicating viral infections. This research aims to identify efficacious bioactive compounds by screening antifungal phytochemicals against the RNA-dependent RNA polymerase (RdRp) protein using a bioinformatic approach to develop an effective treatment for mucormycosis. Methods: The antifungal activity of various phytochemicals against the RNA-dependent RNA polymerase (RdRp) protein was studied using in silico screening. Using the Swiss ADME online server, phytochemicals with proven antifungal properties were assessed to predict the pharmacokinetic aspects and drug-like nature. Furthermore, Molecular docking and toxicity analysis was performed using PyRx and ProTox webserver tools respectively. Results: Among the 1000 antifungal phytochemicals chosen to be evaluated against RdRp, 209 molecules were shortlisted for further studies. The binding affinity scores revealed that Dregamine (-11.1 kcal/mol), Alantolactone (-9.5), Isoalantolactone (-9.5) and Solasodine (-9.5) exhibited the lowest energy value, indicating a strong binding affinity against RdRp. Conclusion: Eventually, the most promising analogues can be further synthesized and evaluated to confirm their actual antifungal activity, allowing them to be used as potent bioactive compounds in the treatment of mucormycosis.
Abstract: Background: Mucormycosis, also referred to as black fungus, is a fatal Angio invasive fungal infection caused by a colony of molds known as mucoromycetes. Rhizopus oryzae is a major fungus that is responsible for almost 70% of the total mucormycosis cases. RNA-dependent RNA polymerase (RdRp), is a crucial enzyme in the RNA polymerization mechanism ...
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Effect of Hydroalcoholic Extract of Stem Bark of Bridelia ferruginea on Blood Coagulation
Messanh Delagnon Irenee Kueviakoe,
Sabrina Chris Janiba Sanvee,
Hezouwe Magnang,
Komlan Mawubédjro Dossou-Yovo,
Aboudoulatif Diallo,
Ahoefa Vovor,
Kwashie Eklu-Gadegbeku
Issue:
Volume 8, Issue 2, June 2022
Pages:
41-45
Received:
1 April 2022
Accepted:
12 May 2022
Published:
24 May 2022
Abstract: Bridelia ferruginea is a plant commonly used in several regions of the world for its various properties. It is offered to certain patients with cerebrovascular accidents. It is with this in mind that this study is undertaken in order to verify whether B. ferruginea has an activity on blood coagulation. Materiel and method: Stem bark of B. ferruginea was collected at Noepe (24 km northwest of Lome). Hydroalcoholic extract (50/50) was obtained by evaporation. Male Wistar rats were used for the tests. Qualitative screening was done according to conventional methods and total phenols were quantified. Some parameters of coagulation (blood platelets, aPTT, PR and fibrinogen) were determined. Oxidative stress was induced by Fe-NTA. Results were analysed by GraphPad®Prism 8.4.2. Analysis of variance (ANOVA) was used to compare several groups. The difference between groups was determined by Tukeyʼs test and considered significant at p<0.05. Results: Hydroalcoholic extract of B. ferruginea increased aPTT and decreased PR. Compared to the negative control (distilled water), oxidative stress was responsible in vivo for an increase in platelets blood number and PR and a decrease in aPTT and fibrinogen. The hydroalcoholic extract of B. ferruginea caused a decrease in platelets blood number (at low concentration), PR and fibrinogen level and an increase in the platelets blood number (at high concentration) and aPTT. Hydroalcoholic extract of B. ferruginea decreased MDA levels and increased GSH levels in rats subjected to oxidative stress. Conclusion: The present study proved existence of antioxidant and anticoagulant activities of B. ferruginea stem bark. There is a link between oxidative stress and coagulation. Future studies may better elucidate interaction between oxidative stress and coagulation mechanisms involved.
Abstract: Bridelia ferruginea is a plant commonly used in several regions of the world for its various properties. It is offered to certain patients with cerebrovascular accidents. It is with this in mind that this study is undertaken in order to verify whether B. ferruginea has an activity on blood coagulation. Materiel and method: Stem bark of B. ferrugine...
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